Effects of Different Enteral Nutrition Timing on Nutritional Status,Intestinal Mucosal Barrier Function and Inflammatory Immune Balance in Patients with Severe Acute Pancreatitis
Objective:To investigate the improvement of intestinal mucosal barrier function,nutritional status and inflammatory immune balance in patients with severe acute pancreatitis(SAP)under different enteral nutrition timing interventions.Methods:120 pa-tients with SAP were divided into group A(enteral nutrition within 48 hours after admission),group B(enteral nutrition 2～5 days after ad-mission)and group C(enteral nutrition 5 days after admission)according to the random number table method,with 40 cases in each group.The nutritional status,intestinal mucosal barrier function,inflammatory index level and immune function in three groups were compared.Results:After treatment,serum albumin(ALB),prealbumin(PA)and transferrin(TRF)levels in group A and group B were higher than those in group C,and those in group A were higher than those in group B(P＜0.05).After treatment,serum endotoxin,diamine oxidase(DAO)and D-Lactate levels in group A and group B were lower than those in group C,and those in group A were lower than those in group B(P＜0.05).After treatment,serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and procalcitonin(PCT)levels in group A and group B were lower than those in group C,and those in group A were lower than those in group B(P＜0.05).After treatment,serum immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in group A and group B levels were higher than those in group C,and those in group A were higher than those in group B(P＜0.05).Conclusion:Enteral nutrition given to patients with SAP within 48 h after admission is conducive to early remission of the disease,while improving nutritional status,intestinal function,and reducing inflammatory immune reaction.
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