Relationship between Serum lncRNA MEG3 and miR-424-5p Levels and the Severity and Prognosis of Children with Acute Respiratory Distress Syndrome
Objective:To analyze the expression of serum long non-coding RNA MEG3(lncRNA MEG3)and microRNA-424-5p(miR-424-5p)in children with acute respiratory distress syndrome(ARDS)and their relationship with the severity and prognosis of the disease.Methods:263 children with ARDS were divided into mild group(n=101),moderate group(n=105)and severe group(n=57)ac-cording to the oxygenation index(OI).According to the prognosis,they were divided into survival group(n=167)and death group(n=96).The levels of serum lncRNA MEG3 and miR-424-5p in mild group,moderate group and severe group were compared.The corre-lation between serum lncRNA MEG3,miR-424-5p levels and the severity of the disease in children were analyzed by Pearson method.The influencing factors of death in children with ARDS were analyzed by univariate and multivariate COX risk regression models.Re-sults:Compared with mild group and moderate group,the serum lncRNA MEG3 level in severe group was significantly lower,the miR-424-5p level and OI were significantly higher(P＜0.05).Compared with mild group,the level of lncRNA MEG3 in moderate group was significantly decreased,and the level of miR-424-5p and OI were significantly increased(P＜0.05).Serum lncRNA MEG3 was nega-tively correlated with OI,and serum miR-424-5p was positively correlated with OI(P＜0.05).OI,miR-424-5p,interleukin-6(IL-6),inter-leukin-17(IL-17)and tumor necrosis factor-α(TNF-α)were independent risk factors affecting the prognosis of children with ARDS,and lncRNA MEG3 was an independent protective factor affecting the prognosis of children with ARDS(P＜0.05).Conclusion:Serum lncR-NA MEG3 and miR-424-5p are closely related to the severity and prognosis of children with ARDS.
Acute respiratory distress syndromelncRNA MEG3miR-424-5pSeverity of diseasePrognosis
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