Relationship between Serum ALP,Copeptin and cTnⅠ Levels and Left Ventricular Aneurysm Formation after PCI in Acute ST-Elevation Myocardial Infarction Patients
Objective:To investigate the relationship between the levels of serum alkaline phosphatase(ALP),copeptin(copeptin)and cardiac troponin Ⅰ(cTnⅠ)and the formation of left ventricular aneurysm(LVA)after percutaneous coronary intervention(PCI)in acute ST-elevation myocardial infarction(STEMI)patients,and to construct a nomogram(Nomogram)prediction model for LVA formation after PCI in STEMI patients.Methods:287 STEMI patients were divided into LVA group(n=63)and non-LVA group(n=224)according to whether LVA was formed after PCI.Influencing factors were analyzed by multivariate Logistic regression analysis;and the Nomogram prediction model was constructed.The predictive value was evaluated by receiver operating characteristic(ROC)curve.Results:The levels of serum ALP,Copeptin and cTnI in LVA group were higher than those in non-LVA group(P＜0.05).Elevated heart rate(HR),creatine kinase isoenzyme(CKMB),N-terminal B-type brain natriuretic peptide(NTpro-BNP),serum ALP,Copeptin and cTnⅠ levels were independent risk factors for LVA formation after PCI in STEMI patients(P＜0.05).The prediction curve of the Nomogram prediction model based on the above risk factors fits well with the ideal curve.Conclusion:The levels of serum ALP,Copeptin and cTnⅠ are abnor-mally high in STEMI patients with LVA after PCI,the elevated levels of HR,CKMB,NTpro-BNP,serum ALP,Copeptin and cTnI are independent risk factors for LVA formation after PCI in STEMI patients.The Nomogram prediction model based on the above risk fac-tors has a high predictive value for LVA formation in STEMI patients after PCI.
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