Application Study of High-Flow Humidified Nasal Cannula in the Intubation Period of Asphyxia in Infants with Pierre-Robin Sequence Syndrome Under General Anesthesia
Objective:To investigate the effect of high-flow humidified nasal cannula(HFNC)on Pierre-Robin sequence syn-drome(PRS)in infants with asphyxia during intubation under general anesthesia.Methods:68 children with PRS who underwent bilateral mandibular distraction osteogenesis(MDO)under general anesthesia were divided into control group and research group by random number table method,with 34 cases in each group.Control group was given routine intubation,and research group was given HFNC on the basis of control group.The number of intubation attempts,intubation time,tracheal extubation time,success rate of first tracheal intu-bation,hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)],blood gas indexes[arterial oxygen partial pressure(PaO2),arterial oxygen saturation(SaO2),arterial carbon dioxide partial pressure(PaCO2)]and incidence of complications were compared be-tween two groups.Results:There were statistically significant differences in the number of intubations,intubation time,tracheal extuba-tion time,and the success rate of first tracheal intubation between the study group and the control group(P＜0.05).HR and MAP increased in both groups after successful intubation(T2)(P＜0.05).There was no significant difference in HR and MAP between the two groups at T2(P＞0.05).PaO2 and SaO2 decreased and PaCO2 increased in both groups at T2 time point(P＜0.05).PaO2 and SaO2 were higher and Pa-CO2 lower in research group than in control group at T2 time point(P＜0.05).The incidence of complications in research group was lower than that in control group(P＜0.05).Conclusion:The application of HFNC in the asphyxial intubation period of PRS children under general anesthesia can effectively reduce the number of intubation attempts,shorten the intubation time and tracheal extubation time,improve the success rate of the first tracheal intubation,improve the hemodynamics and blood gas indexes of the children,and reduce the incidence of complications,the application effect is significant.
High-flow humidified nasal cannulaPierre-Robin sequence syndromeInfantsGeneral anesthesiaIntubation period of asphyxia
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