柴胡加龙骨牡蛎汤联合多巴丝肼片对帕金森病患者氧化应激、肠道菌群和神经营养因子的影响
Effects of Chaihu Plus Longgu Muli Decoction Combined with Levodopa and Benserazide Hydrazine Tablets on Oxidative Stress,Intestinal Flora and Neurotrophic Factors in Patients with Parkinson's Disease
张姝媛 1游佳华 1魏利宁 1白旸 1刘秀英 2王淑玲1
作者信息
- 1. 石家庄市中医院中医脑病科 河北石家庄 050000
- 2. 灵寿县中西医结合医院中医康复科 河北石家庄 050500
- 折叠
摘要
目的:探讨柴胡加龙骨牡蛎汤联合多巴丝肼片对帕金森病(PD)患者氧化应激、肠道菌群和神经营养因子的影响.方法:按照随机数字表法将148例PD患者分为对照组(n=74,多巴丝肼片治疗)和研究组(n=74,柴胡加龙骨牡蛎汤联合多巴丝肼片治疗).比较两组氧化应激指标[过氧化氢酶(CAT)、谷胱甘肽过氧化酶(GSH-Px)]、肠道菌群和神经营养因子[神经生长因子(NGF)、脑源性神经营养因子(BDNF)、胶质源性神经营养因子(GDNF)]水平.结果:治疗后研究组血清BDNF、CAT、NGF、GSH-Px、GDNF、甲型变形菌纲、弯曲菌目、肠杆菌属、拟杆菌属eggerthii菌种相对丰度高于对照组(P＜0.05).结论:柴胡加龙骨牡蛎汤联合多巴丝肼片治疗PD患者,可减轻氧化应激损伤,调节肠道菌群和神经营养因子水平.
Abstract
objective:To explore the effects of chaihu plus longgu muli decoction combined with levodopa and benserazide hy-drazine tablets on oxidative stress,intestinal flora and neurotrophic factors in patients with parkinson's disease(PD).Methods:148 pa-tients with PD were divided into control group(n=74,treated with levodopa and benserazide tablets)and study group(n=74,treated with chaihu plus longgu muli decoction combined with levodopa and benserazide hydrazine tablets)according to the method of randomized numerical table.The oxidative stress indexes[catalase(CAT),glutathione peroxidase(GSH-Px)],intestinal flora and neurotrophic factors[nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),glial-derived neurotrophic factor(GDNF)]levels were compared between two groups.Results:Serum BDNF,CAT,NGF,GSH-Px,GDNF,the relative abundance of Alphapro-teobacteria,Campylobac-terales,Enterobacter and Bacteroides eggerthii in study group were higher than those in control group after treatment(P＜0.05).Conclu-sion:Chaihu plus longgu muli decoction combined with levodopa and benserazide hydrazine tablets in the treatment of PD patients,which can reduce oxidative stress injury,and regulate the levels of intestinal flora and neurotrophic factors.
关键词
柴胡加龙骨牡蛎汤/多巴丝肼片/帕金森病/氧化应激/肠道菌群/神经营养因子Key words
Chaihu plus longgu muli decoction/Levodopa and benserazide hydrochloride tablets/Parkinson's disease/Oxidative stress/Intestinal flora/Neurotrophic factors引用本文复制引用
出版年
2024
NETL
NSTL
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