MicroRNAs(miRNAs)are a type of endogenous,non-coding,single-stranded RNA that specifically regulates post-transcriptional gene expression in eukaryotic cells.In recent years,miRNA regulation has been utilized in the design of oncolytic viruses.By inserting a target sequence of a tissue-specific miRNA that is down-regulated in the tumor into the viral genome,the tissue tropism of the oncolytic virus can be altered,and the anti-tumor activity of the virus can be remained during viral attenuation.Additionally,natural or artificially modified miRNAs can be inserted and expressed in viral genomes to promote viral replication and improve the tumor microenvironment,thereby enhancing the therapeutic effect of oncolytic viruses.This paper reviews and discusses the utilization of miRNA regulation in oncolytic virology,with the aim of providing insights into the optimization of existing oncolytic virotherapy strategies.
维普
万方数据