Carbon dioxide(CO2)as the next-generation feedstock for bio-manufacturing holds significant importance for achieving low-carbon,green,and sustainable development.The development of CO2 bioconversion technology contributes to reducing greenhouse gas emissions,facilitating carbon neutrality goals,and driving economic growth and industrial innovation,playing a crucial role in building a sustainable future.This study presents the current development status and research activities of CO2 bioconversion technology by systematically investigating global policy frameworks,scientific advancements,and industrialization efforts.The research reveals that major countries and regions such as the United States,European Union,United Kingdom,and Japan have introduced strategies for carbon-negative bio-manufacturing.Key research focuses include strain exploration,metabolic engineering,scale-up production,product innovation and process improvement.However,the industrialization of CO2 bioconversion faces challenges such as limited product categories and high production costs.Therefore,this paper suggests that governments and industries implement incentive measures and create an environment conducive to technological innovation and industrial transformation.