Progress in Understanding the Interaction between Metabolic Enzymes and RNA
Cellular metabolic reprogramming plays an important role in maintaining cellular homeostasis,cell growth and proliferation,and is widely involved in pathological processes such as malignant transformation.With the development of high-throughput molecular detection technology,it has been found that some metabolic enzymes can not only participate in the regulation of cellular metabolism by catalyzing a variety of intracellular biochemical reactions,but also bind to RNA molecules.These metabolic enzymes do not have classical RNA-binding domains,and it has been shown that they can regulate the transport,stability,or translation of their binding mRNA through a negative feedback mechanism,thereby linking the regulation of gene expression to cell metabolism.In addition,the metabolites of enzymes may also be involved in the regulation of the interaction between RNA and metabolic enzymes.This study reviews metabolic enzymes with RNA-binding ability,the interaction between metabolic enzymes and RNA,the identification and verification of RNA binding protein,metabolic regulation mechanisms,and how the interaction between these metabolic enzymes and RNA regulates complex cellular activities and the onset and development of disease.
NETL
NSTL
万方数据
