细胞免疫治疗载体技术的现状与展望
Current Status and Prospects of Cellular Immunotherapy Vector Technology
刘秀盈 1刘静静 1崔鑫铭 1于梦圆 1史渊源 2王建勋2
作者信息
- 1. 北京中医药大学生命科学学院 北京10000
- 2. 北京中医药大学生命科学学院 北京10000;深圳细胞谷生物医药有限公司 深圳 518000
- 折叠
摘要
近年我国细胞免疫治疗发展迅速,从零基础直追国际前沿水平.在细胞免疫疗法蓬勃发展的背后,将基因导入靶细胞并使其进行表达的基因递送载体技术的支持不可或缺.如何更加安全高效地进行基因转递也是困扰行业发展的重要瓶颈之一.通过总结目前细胞治疗领域主要应用的载体技术发展现状,并对比已经上市产品的工业化生产流程,以期为后续载体技术的发展提供参考.
Abstract
In recent years,China's cellular immunotherapy has developed rapidly,catching up from zero to the international level of excellence.Behind the booming development of cellular immunotherapy,the support of vector technology for gene delivery is indispensable.As a medium for introducing genes into target cells and enabling their expression,vector technology is also one of the major bottlenecks in the development of the industry in terms of how to carry out gene transfer safely and efficiently.By summarizing the current status of the development of vector technology for major applications in the field of cell therapy and comparing the industrialized production process of already marketed products,we hope to provide a reference for the further development of vector technology.
关键词
细胞免疫治疗/基因递送载体/工业化生产Key words
Cellular immunotherapy/Gene delivery vectors/Industrial production引用本文复制引用
基金项目
高层次人才科研启动基金(9011451310032)
出版年
2024
NETL
NSTL
万方数据