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细胞免疫治疗载体技术的现状与展望

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近年我国细胞免疫治疗发展迅速,从零基础直追国际前沿水平.在细胞免疫疗法蓬勃发展的背后,将基因导入靶细胞并使其进行表达的基因递送载体技术的支持不可或缺.如何更加安全高效地进行基因转递也是困扰行业发展的重要瓶颈之一.通过总结目前细胞治疗领域主要应用的载体技术发展现状,并对比已经上市产品的工业化生产流程,以期为后续载体技术的发展提供参考.
Current Status and Prospects of Cellular Immunotherapy Vector Technology
In recent years,China's cellular immunotherapy has developed rapidly,catching up from zero to the international level of excellence.Behind the booming development of cellular immunotherapy,the support of vector technology for gene delivery is indispensable.As a medium for introducing genes into target cells and enabling their expression,vector technology is also one of the major bottlenecks in the development of the industry in terms of how to carry out gene transfer safely and efficiently.By summarizing the current status of the development of vector technology for major applications in the field of cell therapy and comparing the industrialized production process of already marketed products,we hope to provide a reference for the further development of vector technology.

Cellular immunotherapyGene delivery vectorsIndustrial production

刘秀盈、刘静静、崔鑫铭、于梦圆、史渊源、王建勋

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北京中医药大学生命科学学院 北京10000

深圳细胞谷生物医药有限公司 深圳 518000

细胞免疫治疗 基因递送载体 工业化生产

高层次人才科研启动基金

9011451310032

2024

中国生物工程杂志
中国科学院文献情报中心 中国生物技术发展中心 中国生物工程学会

中国生物工程杂志

CSTPCD北大核心
影响因子:0.589
ISSN:1671-8135
年,卷(期):2024.44(2)
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