Analysis of the Development Trend of Targeted Protein Degradation Technology
Targeted protein degradation(TPD)technology refers to a type of technology that utilizes the internal naturally occurring protein purification system to reduce target protein levels.By analyzing the status of basic research and industrial development status of TPD,it can be seen that the development of TPD has entered the fast lane in recent years.With the progress of research,the resources of degradable target protein and recruitable E3 ubiquitin ligase have been expanded,and the stability and efficacy of TPD have been further improved,which realizes controllable and precise degradation.At the same time,the target protein has been expanded from intracellular proteins to extracellular and membrane-binding proteins,protein aggregates,and non-protein substances such as RNA,lipids,organelles,and pathogens based on technological prototype innovation.TPD technology has also provided new ideas for the development of new drugs against undruggable targets,ushering in a new wave in the pharmaceutical industry,and opening up new avenues for the treatment of diseases such as cancer and autoimmune diseases.
Targeted protein degradationTarget proteinUndruggable
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