外泌体与肺纤维化研究进展
Research Progress on Extracellular Vesicles and Pulmonary Fibrosis
叶灏鑫 1王晓旭 1李明霏 1王宇1
作者信息
摘要
肺纤维化是一种由肺泡外基质蛋白过度沉积导致的肺部不可逆的结构和功能改变的肺部疾病,表现为纤维化重构和肺泡破坏.外泌体作为一种细胞外囊泡,可通过递送特定细胞类型产生的功能性核酸和蛋白质来介导细胞间通讯.近年来的研究发现,外泌体在肺纤维化的诊断和治疗中具有重要作用,被认为是一种潜在的生物治疗方法和药物递送载体.研究外泌体在肺纤维化发生发展中的作用,以期为肺纤维化的外泌体治疗研究提供新的思路.
Abstract
Pulmonary fibrosis is a disease characterized by irreversible structural and functional changes in the lung caused by excessive deposition of extracellular matrix proteins,resulting in fibrotic remodeling and alveolar destruction.As extracellular vesicles,exosomes can mediate intercellular communication by delivering functional nucleic acids and proteins produced by specific cell types.Recent studies have shown that exosomes play an important role in the diagnosis and treatment of pulmonary fibrosis and are considered to be a potential biological treatment method and drug delivery carrier.This review aims to summarize the current research on the role and therapeutic application of exosomes in pulmonary fibrosis,and to provide insights into the future development direction and prospects of exosome research,so as to provide new ideas for the treatment of exosomes in pulmonary fibrosis.
关键词
外泌体/肺纤维化/细胞外囊泡/药物递送载体/诊断和治疗Key words
Exosomes/Pulmonary fibrosis/Extracellular vesicles/Drug delivery vehicle/Diagnosis and treatment引用本文复制引用
基金项目
河北省自然科学基金(H2021201040)
河北大学医学学科培育项目(2021A02)
出版年
2024
NETL
NSTL
万方数据