首页|动物细胞培育肉及其种子细胞优选与永生化策略

动物细胞培育肉及其种子细胞优选与永生化策略

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鉴于传统养殖和屠宰获取肉类食品的方式,环境污染、资源浪费和多种有害成分残留等方面问题不断加剧,以及未来绿色低碳发展所面临的现实问题,随着"细胞农牧"科技的兴起,国内外研究者和企业家将目光转向了具有综合优势的细胞培育肉生产新模式.与以多种蛋白质资源为原料进行调制加工的"植物人造肉"不同,动物细胞培育所生产细胞培育肉,在营养品质和口感上更接近"真肉",有望成为细胞合成生物技术生产替代蛋白质的未来发展新热点,已成为新兴食品科技和产业与投资界的新宠.将细胞培育成具有一定规模和效率的"培育肉",将对生长效率与周期,以及规模化生产的成本控制具有基础性作用,其中最为关键的是种子细胞及其永生化扩增能力.主要就国内外有关动物细胞培育肉概况、种子细胞优选与实现其永生化策略,以及动物细胞培育肉方面科技伦理等进行较为系统的综述和分析,为我国开展相关研究和细胞培育肉产业提供重要参考.
Animal Cell Cultured Meat and Its Seed Cell Selection and Immortalization Strategies
In view of the increasing impact of traditional meat production methods through farming and slaughtering on environmental pollution,waste of resources and residues of various harmful ingredients,as well as the practical problems facing the future green and low-carbon development,with the rise of"cell farming"technology,Chinese and international researchers and entrepreneurs have turned their attention to the new production model of"artificial meat"with multiple advantages,and have achieved results.Unlike the plant-based"artificial meat",which is processed using various protein sources as raw materials,the"artificial meat"produced by cultivating animal cells,or"cell-cultured meat",is closer to"real meat"in terms of nutritional quality and taste.It is expected to become a new popular theme for the future development of alternative protein production based on cell-synthesis biotechnology,and is a new favorite of emerging food technology,industry,and investment circles.However,the key to cultivating meat with a certain scale and efficiency from the initial cells is the seed cells and their ability to be immortalized and expanded,which will play a fundamental role in growth efficiency and cycle,as well as cost control in large-scale production.This article mainly summarizes and analyzes the cultivation of meat from animal cells at home and abroad,the selection of seed cells and the implementation of their immortalization strategy,as well as the scientific and ethical aspects of animal cell-cultured meat,providing important references for relevant research and the artificial meat industry in China.

Animal cell cultured meatSeed cell selectionStem cellImmortalizationArtificial meatTechnological ethics

仝西魁、付云辉、郑文云、王阳敏、马兴元

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华东理工大学 生物工程学院 生物反应器工程国家重点实验室 上海 200237

华东理工大学 药学院 上海市新药设计重点实验室 上海 200237

动物细胞培育肉 种子细胞优选 干细胞 永生化 人造肉 科技伦理

国家重点研发计划(合成生物学专项)企业横向项目

2018YFA0902804Y100-81832

2024

中国生物工程杂志
中国科学院文献情报中心 中国生物技术发展中心 中国生物工程学会

中国生物工程杂志

CSTPCD北大核心
影响因子:0.589
ISSN:1671-8135
年,卷(期):2024.44(5)