Advances of Biological Nanopores in Amino Acid Detection and Sequence Recognition
Amino acids are essential components of living organisms,providing the basic building blocks for many life processes.They undergo dehydration-condensation reactions to form peptides,which are then coiled and folded into proteins.The structural and functional differences betweeen peptides and proteins are strongly influenced by different amino acid sequences.It is therefore of great significance to detect amino acids and identify the amino acid sequence.Nanopore technology is a novel single-molecule detection technology that offers the advantages of label-free detection,high sensitivity,and rapid analysis.It has been widely applied to the detection of nucleic acids,proteins,and polysaccharides.This article provides a comprehensive review of the application of nanopores in amino acid detection,peptide and protein detection,and amino acid sequence identification.Furthermore,the prospects in this field are also included.
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