Research Progress in Novel Electrochemical Sensors for Biomolecular Detection
The need for self-directed health monitoring has been steadily increasing as the call for"improving the health literacy of the whole nation"has been favorably received,and metabolite analysis plays an indispensable role in the process of health management.Compared to traditional analytical techniques such as mass spectrometry,chromatography and spectroscopy,electrochemical sensors have shown great potential for applications in biomedical,environmental,and material sciences due to their high selectivity,high sensitivity,and wide detection range.Currently,researchers have developed several electrochemical sensors focused on the detection of biometabolites,both for the determination of disease markers in isolated body fluids and for real-time dynamic in vivo monitoring.Taking biomolecular detection as the starting point,we review and compare the research progress in portable,implantable,and wearable electrochemical sensors for the analysis of disease-related metabolites and their comparison,which may provide a reference for the generation of novel sensors and the expansion of clinical applications.
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