Research Progress on Extracellular Vesicle Delivery CRISPR/Cas9 System
The CRISPR/Cas9 system,known for its efficient and easy gene-editing capabilities,is widely preferred and extensively used in various fields,attracting considerable attention from researchers both domestically and internationally.Extracellular vesicles,as natural nanoscale carriers with abundant sources,are proving to be a highly attractive delivery vehicle for the CRISPR/Cas9 system.Compared to conventional viral or non-viral vectors,extracellular vesicles offer significant advantages in terms of safety,capacity,penetrability,targeting specificity,and transformative potential.They are poised to become the optimal carriers for delivery of the CRISPR/Cas9 system.This article summarizes common delivery strategies and loading methods for the CRISPR/Cas9 system,contrasts extracellular vesicles with other carriers,and provides a comprehensive review of the advantages,domestic and international research progress,and applications of extracellular vesicles in delivering the CRISPR/Cas9 system.The goal is to contribute to the advancement of the field of gene-editing delivery.
NETL
NSTL
万方数据
