Extracellular vesicles(EVs)are cell-derived nanovesicles that can deliver bioactive cargoes among cells or organs,including proteins,nucleic acids and metabolic molecules.Recently,mitochondrial contents-containing EVs(mitoEVs)were identified as a new subtype of EVs,containing mitochondrial DNA,proteins,and damaged or active mitochondria.Secretion of mitoEVs contributes to maintaining homeostasis of donor cells,rescuing the metabolic status of recipient cells and participating in the regulation of immune microenvironment.The biological information carried by mitoEVs could serve as crucial targets for disease diagnosis,and the active mitochondrial components had proved potential therapeutic effects in various diseases.In conclusion,summarizing the formation mechanism,function,isolation and characterization of mitoEVs,and prospecting its future clinical application prospects,can provide potential targets and insights for the development and treatment of disease diagnostic markers.
MitochondriaExtracellular vesicleMitochondrial contents-containing EVsMitochondrial quality control
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