L-Alanyl-L-Glutamine(Ala-Gln)is an important dipeptide that can be decomposed as L-glutamine(L-Gln)in the body,which plays an irreplaceable physiological and biochemical roles.The traditional chemical synthesis method suffers from the disadvantages of high pollution,low conversion,and low purity,and is accompanied by the generation of toxic by-products,which limits its large-scale application.With the rapid development of biology,researchers have analyzed the synthetic methods of Ala-Gln and directed the modification of strains,which opens up a new era for the green and efficient production of Ala-Gln.This paper reviews the application of Ala-Gln,the metabolic pathways of Ala-Gln synthesized by traditional chemical synthesis and microbial synthesis,and the progress of microbial production of Ala-Gln,with the aim of exploring the use of synthetic biology to optimize the metabolic pathway of Ala-Gln,providing a theoretical basis for the efficient production of Ala-Gln,and promoting the industrial production of Ala-Gln.
NETL
NSTL
万方数据
