Development Trend of CAR-T Process Driven by High Cost
In recent years,with the rapid development of science and technology,chimeric antigen receptor T cell(CAR-T)products have made breakthroughs in molecular design and manufacturing technology.Meanwhile,the indications for CAR-T have gradually expanded from hematological cancers to autoimmune diseases and solid tumors.However,high costs and low capacity are the major practical problems facing CAR-T products nowadays,severely limiting their clinical application.The most important factors that lead to the high cost of CAR-T products include the high price of raw materials,the cost of quality control and facilities/equipment that cannot be diluted under the customized production model,and the high labor cost caused by technology dependence.In this paper,we have analyzed the specific factors that cause the high cost of CAR-T products,proposed some targeted solutions,and summarized the development trend to provide some references and suggestions for reducing the cost of CAR-T cell manufacturing.The improvement of gene transduction technology,especially the development of non-viral transduction systems,the exploration of universal cell therapy products,and the industridl layout of domestically produced automation equipment are all the important directions for the future development of CAR-T technology.It is believed that with the continuous efforts of researchers,the cost of CAR-T products will be greatly reduced,and the CAR-T products will eventually become a"civilian"treatment drug for patients,providing more treatment options for seriously ill patients.
CAR-TCost reduction and efficiency increaseUniversal CAR-TAutomated productionline Cytotherapy
万方数据
维普
