Pluripotent Stem Cells for the Treatment of Retinal Degenerative Diseases:Current Situation and Challenges from Bench to Bedside
Alzheimer's disease(AD)is a neurodegenerative disease that causes progressive impairment of cognition and memory,affecting more than 50 million people worldwide and placing an increasing burden on society.The pathology of AD is characterized by a complex set of features,including deposition of β-amyloid and hyperphosphorylation of Tau proteins,as well as loss of synaptic connectivity.Neural stem/progenitor cells(NSPC)are a specialized type of cells with the ability to self-renew and differentiate pluripotently into various types of neurons and glial cells,and NSPC transplantation therapy has attracted much attention for its ability to promote the restoration of synaptic connectivity and function to ameliorate the symptoms of AD.The article highlights the current state of research on NSPC transplantation in animal models of AD,as well as recent advances in clinical trials of stem cell therapy for AD.In addition,the review highlights the issues and challenges facing NSPC transplantation.It will provide important guidance and insights for the development of innovative therapeutic approaches and clinical practices to improve the quality of life of AD patients.
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