Advances in the Basis and Application of Mycobacteriophages
Infectious diseases caused by mycobacteria have become a major public health problem worldwide.The emergence of drug-resistant mycobacteria is making prevention and control more difficult.There is an urgent need for new treatments.Some progress has been made in the study of bacteriophages in this regard.In nature,phages are abundant and capable of infecting bacterial microorganisms.To date,more than 2 400 whole genomes of mycobacteriophages have been sequenced,and the results show that the genome of mycobacterium phages has a rich diversity and mosaic structure.The peptides and proteins,encoded by the genome with anti-tuberculosis activity have great potential in the diagnosis and treatment of mycobacterial infections.In practical application,bacteriophage is not only used to directly treat infectious diseases,but also as an efficient tools for gene editing systems.The advantage of phage treatment is that the specific phage will not infect mammals and other bacteria in the body.Here,we review the potential application of mycobacteriophages in the diagnosis,treatment and prevention of mycobacterial infections,discuss the application prospects of mycobacteriophages,and analyze their advantages and disadvantages in basic application research.
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