Research Progress on Pseudomonas aeruginosa Phage Resistance
Pseudomonas aeruginosa is a common opportunistic pathogen and a frequent cause of nosocomial infections.This bacterium is resistant to most currently available antibiotics and has emerged as one of the top six pathogens causing resistance-related deaths worldwide.Bacteriophages(phages)are viruses that specifically infect bacteria and have potential application prospects in controlling infections caused by antibiotic-resistant P.aeruginosa.However,the rapidly evolving resistance of P.aeruginosa to phages affects the efficacy of phage applications.This study reviews the progress of phage-resistant P.aeruginosa,focusing on the phenotypic changes of phage-resistant P.aeruginosa,the mechanisms of phage resistance,and the main strategies to overcome the phage resistance of P.aeruginosa,providing insights into the application of phages to prevent and control P.aeruginosa infections.
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