Advances in the Type Ⅳ Secretion System of Antimicrobial Resistant Plasmids and Plasmid-dependent Phages
Antimicrobial resistance has been recognized as a major threat to human health in the 21st century.Conjugation is the most important pathway for the horizontal gene transfer of antimicrobial resistance genes in bacterial communities,especially among Enterobacteriaceae.The type Ⅳ secretion system(T4SS)plays a key role in the bacterial conjugation process.T4SS is a macromolecular transport system,which includes a type Ⅳ-coupled protein,an inner membrane complex,an outer membrane complex and a conjugative pilus.In recent years,targeting at T4SS has emerged as a novel strategy to combat antimicrobial resistance.In this review,we mainly summarize the research progress on the plasmid-dependent bacteriophages,especially T4SS-targeting phages.
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