Dihydroquercetin(DHQ),also known as taxifolin,is a natural dihydroflavonoid,which has attracted considerable attention due to its high antioxidant activity and great market potential.It has been widely used in medicine,food and health products.Recently,the in-depth study of DHQ has greatly broadened its application and its development prospects.DHQ is traditionally derived from plant tissues.However,the source of raw materials and the production process pose serious challenges to traditional production methods,and new production methods represented by biosynthesis will be key to solving this problem.To this end,the review summarizes the main approaches for the preparation of DHQ,the main research results of DHQ biosynthesis and the latest progress in its biological activities such as antioxidant,organ protective,anti-tumor,anti-inflammatory,antibacterial,and antiviral activities in recent years,in order to provide an important reference for the application and development of DHQ.