Metals and Their Composites in Diabetic Wound Healing
Chronic wounds in diabetes remain a major clinical and research challenge.Due to the vicious cycle of oxidative stress,bacterial infection,excessive inflammatory response,and impaired angiogenesis,the healing process of diabetic wounds is disrupted,leading to the formation of chronic wounds.Although a variety of clinical methods have been investigated for the treatment of diabetic wounds,the results have not been satisfactory.Metals and their composites are expected to solve these problems.The study found that metal ions are involved in the synthesis and transformation of a variety of enzymes and proteins,thereby affecting a range of cellular activities.However,due to the sudden release and cytotoxicity of metal ions,it is necessary to modify them.At present,silver(Ag),copper(Cu),zinc(Zn),gold(Au)and other metals as nanoparticles and metal-organic skeleton,as well as their composites combined with biological materials(such as chitosan,sodium alginate,and antibiotics)have been widely used and studied in diabetic wounds.In vitro experiments showed that the metals and their composites had good biocompatibility and stability,and inhibited the growth and reproduction of bacterial strains commonly found in diabetic wounds,including gram-positive and gram-negative bacteria.They demonstrated excellent anti-inflammatory,antioxidant,antibacterial and angiogenic properties,and ultimately promoted the healing of diabetic wounds.In summary,metals and their composites not only play a role in various stages of diabetic wound healing,but also provide a stable physiological environment for the process of diabetic wound healing,which is a promising new strategy for the treatment of diabetic wound healing.
Metal nanoparticlesMetal-organic frameworkBiomaterialsDiabetic wound healing
万方数据
维普
