Recent Advances in Novel and Universal Influenza A Prevention Vaccines
Influenza is a highly contagious respiratory disease caused primarily by the influenza A virus.Influenza vaccine is one of the most economical and effective ways to prevent and control the widespread epidemics of influenza A viruses.Although various types of vaccines developed over the years have played a certain role in preventing and controlling influenza A virus infection,it is common that the antigens of vaccines and circulating strains do not match due to the existence of multiple subtypes of influenza viruses and their easy mutation and recombination,which often results in the injected vaccine not having a protective effect and frequent changes of vaccines.To effectively address this thorny problem,some research institutions and vaccine companies have turned to the development of universal or broad-spectrum influenza vaccines and have high expectations.This article systematically reviews the traditional influenza vaccines and the newly approved universal vaccines,both domestically and internationally.In particular,it highlights recent advances in DNA/mRNA vaccine research and development.It also discusses the future direction of universal influenza vaccine development.The aim is to provide guidance and support for the development of efficient and broad-spectrum new influenza vaccines,and to provide an important theoretical reference and technical basis.
Influenza ATraditional influenza vaccineNovel influenza vaccineBroad-spectrum influenza vaccinemRNA vaccine development
万方数据
维普
