Research Progress of Bacteria and Their Derivatives in the Combination Therapy of Tumors
Cancer remains one of the leading causes of human mortality.Despite significant advances in cancer treatment by modem medicine,traditional therapeutic approaches still face limitations,including inadequate targeting and significant toxic side effects.Nevertheless,the emergence of technological advancements has brought a ray of hope in tumor treatment through the utilization of bacteria and their derivatives,which have unique biological properties.Bacteria,due to their inherent survival characteristics,exhibit highly effective tumor-targeting colonization and direct tumor cell killing capabilities while being amenable to genetic engineering.Consequently,through genetic modification,bacteria and their derivatives can be used as efficient drug delivery vehicles,seamlessly integrating various treatment modalities,including radiotherapy,chemotherapy,and immunotherapy.The combination aims to overcome therapeutic deficiencies,increase the efficacy of tumor treatment,and minimize toxic side effects.This review comprehensively summarizes the latest research progress in optimizing combination therapy strategies using bacteria and their derivatives for tumor treatment.Specifically,it explores the advantages of utilizing bacteria and their derivatives as drug carriers in tumor treatment and outlines methods for engineering bacteria for drug delivery,and elucidates strategies for optimizing combination therapy.The primary objective is to provide a theoretical basis for optimizing anti-tumor treatment strategies,ultimately unlocking the therapeutic potential of bacteria,enhancing the effectiveness of anti-tumor treatment,and providing safer and more effective treatment options for people fighting cancer.
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