干细胞治疗肝衰竭研究进展
Research Progress in Stem Cell Therapy for Liver Failure
游昌乔 1刘爱龙 2张红明 2李灿 2丁云云 3丁浩2
作者信息
- 1. 湖南南华生物技术有限公司 长沙 410221;湖南大学生物学院 长沙 410012
- 2. 湖南南华生物技术有限公司 长沙 410221
- 3. 湖南大学生物学院 长沙 410012
- 折叠
摘要
肝衰竭是一种严重的肝脏疾病,其临床治疗面临极大挑战.多种因素,如慢性肝病、病毒性肝炎感染和药物滥用等,均可诱发肝衰竭,对数以千计患者的生命安全造成威胁.近年来,干细胞治疗作为一种新兴的治疗方法,通过促进肝细胞修复与再生、调节免疫反应、抑制肝纤维化和炎症反应等机制,为肝衰竭治疗提供了新思路.多项临床研究已经证明,干细胞移植治疗可以显著提高肝衰竭患者的存活率,并有效改善肝功能和凝血功能.然而,关于其长期疗效和安全性仍需进一步研究来确认.通过总结干细胞治疗肝衰竭的研究进展,并探讨其潜在的治疗机制和临床应用前景,有望为未来的研究和临床实践提供参考.
Abstract
As a serious liver disease,the clinical treatment of liver failure faces significant challenges.Chronic liver disease,viral hepatitis infection,drug poisoning,and other factors can lead to liver failure,threatening the lives of thousands of patients.In recent years,stem cell therapy has emerged as a novel treatment method,offering a new approach to the treatment of liver failure.It works by promoting the repair and regeneration of liver cells,regulating the immune response,and inhibiting liver fibrosis and inflammation.Several clinical trials have demonstrated that stem cell transplantation therapy can significantly improve the survival rate of patients with liver failure.It also effectively improves liver function and blood clotting function.However,further studies are needed to confirm its long-term effectiveness and safety.This paper summarizes the research progress of stem cell therapy for liver failure,discusses its potential therapeutic mechanism,and explores its prospects for clinical application.The aim is to provide a reference for future research and clinical practice.
关键词
干细胞/肝衰竭/治疗机制/肝细胞/修复与再生Key words
Stem cell/Liver failure/Mechanisms of treatment/Hepatocyte/Repair and regeneration引用本文复制引用
出版年
2024
NETL
NSTL
万方数据