L-homophenylalanine(L-HPA)is an important non-natural amino acid that has been used as a key intermediate for the synthesis of Puli drugs for the treatment of hypertension.At present,L-HPA is synthesized using chemical methods,which has the disadvantages of expensive raw materials,tedious steps and serious pollution.Therefore,researchers have conducted in-depth research on the enzymatic production of L-HPA.This review summarizes the research progress on the enzymatic synthesis of L-HPA,including the dehydrogenase process,the transaminase process,the hydantoinase process,and the decarboxylase process,with the hope to facilitate the industrial production of L-HPA.
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