Triple-negative breast cancer(TNBC)is the most malignant subtype of breast cancer.Currently,chemotherapy remains to be the primary treatment for TNBC,but drug resistance is common while patient prognosis is poor.With the development of proteomics technology,phosphoproteomics research has made great progress and has been widely used in the study of tumor mechanism,diagnosis and treatment.Similarly,phosphoproteomics plays a significant role in the studies of the occurrence,development,targeted therapy,and drug resistance mechanisms of TNBC.This article summarizes the research progress of phosphoproteomics in TNBC,with the aim to facilitate the research on the mechanism and treatment of TNBC based on phosphoproteomics.
关键词
蛋白质组学/磷酸化蛋白质组学/三阴性乳腺癌
Key words
proteomics/phosphoproteomics/triple-negative breast cancer
维普
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