Antimicrobial peptides(AMPs)are small molecular peptides widely existing in the innate immunity of organisms,serving as the first line of defense.Natural AMPs possess various biological activities and are difficult to develop drug resistance.However,they are easily broken down by digestive enzymes in the body.In recent years,increasing methods have been reported to enhance the stability of AMPs,including incorporation of unnatural amino acids,chemical modifications,strategic avoidance of enzyme cleavage sites,cyclization,and nano peptide design.This review summarizes the methods for improving the stability of AMPs against protease degradation,aiming to provide references for further research in this field.
关键词
抗菌肽/蛋白酶稳定性/非天然氨基酸/化学修饰/残基排布/环化/纳米技术
Key words
antimicrobial peptide/protease stability/unnatural amino acids/chemical modification/arrangement of residues/cyclization/nanotechnology
维普
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