摘要
胡蜂毒肽(mastoparans,MP)是一类昆虫源的α-螺旋阳离子抗菌肽,具有广谱的抗微生物活性,对细菌、真菌、病毒及寄生虫的生长均有一定的抑制作用.通过氨基酸替换、肽段结构修饰、肽链环化及剂型改造等多种方法进行多肽改造,可增强胡蜂毒肽的生物学活性和靶向性,并降低其毒性.本文对胡蜂毒肽的结构、生物学功能及其修饰改造方法进行综述,并对以胡蜂毒肽为基础的抗菌药物研发进行了展望,为胡蜂毒肽作为新型抗微生物药物的研究提供了参考.
Abstract
Mastoparans(MP),a class of α-helix cationic insect-derived antimicrobial peptides,have a broad spectrum of biological activities including inhibiting bacteria,fungi,viruses,and parasites.Amino acid substitution,peptide modification,peptide chain cyclization,and dosage form modification can enhance the biological activities and target and reduce the toxicity of mastoparans.In this review,we summarize the structure,biological function and modification methods of mastoparans,and prospect the development of antibacterial drugs based on mastoparans,so as to provide reference for the research of mastoparans as a new antibacterial drug.
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