Embryo implantation involves a complex interaction between the embryo and the endometrium of the mother,the study of which faces a variety of problems.The modeling of endometrial epithelial organoids and endometrial assembloids provides a new way to study the process of embryo implantation in vitro.This paper summarized the latest research progress in embryo implantation,the regulation mechanism of endometrial receptivity by estrogen-progesterone coordination and embryo-derived signals,the establishment of endometrial organoids,and the development and application of endometrial assembloids in the research on mother-embryo interaction,providing new strategies for studying the communication between embryo and maternal uterus during implantation.
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