Objective:To prepare a multi-sensitive gel by modifying natural polymers,and to prepare a carrier material that can be used for drug sustained release.Methods:SPI/AGC gel is prepared by soy protein isolate(SPI)with chitosan(CS)and acrylamide(AM),ammonium persulfate(APS)as initiator,N,N′-methylenebisacrylamide(MBA)as crosslinking agent.The sensitivity and release properties of SPI/AGC hydrogel are tested in vitro.Results:SPI/AGC gel possessed pH sensitivity and better swelling performance.The larger the pH value of solution,the better the swelling ability.The load and in vitro release of the model drug 5-fluorouracil(5-FU)show that the cumulative release rate of 5-FU reache the maximum value(67.27%)by SPI/AGC after 84 h release in artificial intestinal fluid,which shows good sustained release performance.Conclusion:SPI/AGC gel prepared in this paper has a wide application prospect in the field of biomedicine.
soybean protein isolatehydrogelmultiple sensitivitiescontrolled release
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