Research on Differences of Metabolite Profiling and Metabolic Stability of the Main Ingredients of Yao-Bi-Tong Capsule in the Different Species of liver Microsomes
This study aimed to investigate phase I metabolism of the main ingredients of Yao-Bi-Tong Capsule and compare the difference of their metablite profile and metablic stability in the different species of liver microsomes(human,cynomolgus monkeys,beagle dogs,SD rats and mouse)through liver microsomal incubation technique.UPLC-Q-TOF technology is used to find the possible metabolites in the incubated samples.UPLC-TQ technology is used to determine the change of the content of the main components in the incubated samples.The results show that phase I of osthole has some significant differences on the metablite profile and metabolic stability in five different species of liver microsomes.However,metabolism of other main ingredients is relatively stable and their metabolic difference are not significant in different species of liver microsomes.
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