黄连素干预C57BL/6小鼠牙周炎和牙菌斑的影响观察
Effect of Berberine on Periodontitis and Dental Plaque in C57BL/6 Mice
朱雨洁 1康杰 1赵宁 1李昕吉 1贾波1
作者信息
摘要
目的:探讨黄连素(BBR)抑制牙菌斑生长从而治疗牙周炎的作用.方法:选取C57BL/6 雄性小鼠 21 只,随机分为3 组(对照组、牙周炎模型组、BBR治疗组),模型构建成功后用BBR对治疗组进行 4 周的干预措施,观察并记录每组小鼠的一般情况、牙周炎症状和菌斑染色情况.结果:相较于对照组,牙周炎模型组小鼠表现出萎靡不振、食欲及体质量下降,经BBR治疗后小鼠的食欲和体质量有一定的恢复;BBR治疗组的牙龈指数(GI)、牙龈出血指数(GBI)、改良龈沟出血指数(mSBI)均低于模型组;经BBR治疗后,治疗组牙周情况得到显著改善,治疗组小鼠的牙菌斑数量低于牙周炎模型组.结论:BBR对牙周炎和牙菌斑的发生发展有显著抑制效果.
Abstract
Objective:To investigate the inhibitory effect of berberine(BBR)on periodontitis and dental plaque growth.Methods:Twenty-one male C57BL/6 mice are selected and randomly divided into 3 groups(control group,periodontitis model group,BBR treatment group).After successful model construction,the treatment group is treated with berberine for 4 weeks.The general condition,periodontitis symptoms,and plaque staining of each group of mice are observed and recorded.Results:Compared with the control group,the mice in the periodontitis model group shows malaise,appetite and weight loss,and the appetite and weight of the mice after BBR treatment has a certain recovery.The gingival index(GI),gingival bleeding index(GBI)and modified gingival sulci bleeding index(mSBI)in BBR treatment group are lower than those in model group.After treatment with BBR,the periodontal condition of the treatment group is significantly improved,and the amount of plaque in the treatment group is lower than that of the periodontitis model group.Conclusion:BBR can significantly inhibit the occurrence and development of periodontitis and dental plaque.
关键词
牙周炎/牙菌斑/黄连素Key words
periodontitis/dental plaque/berberine引用本文复制引用
基金项目
湖南省大学生创新创业训练计划项目(湘教通[2022]174号-4599)
湖南省教育厅科学研究项目一般项目(21C0882)
出版年
2024
NETL
NSTL
万方数据