Parkinson's Disease(PD)is a highly prevalent neurodegenerative disease in middle-aged and elderly people.Cordyceps militaris is a traditional edible and medicinal fungus in Southeast Asia.This review systematically summarizes the recent advances in the neuroprotective effects of Cordyceps militaris in PD,focusing on its molecular mechanisms in dopamine regulation,anti-apoptosis,anti-oxidation,anti-inflammation,anti-endoplasmic reticulum stress and regulating mitochondrial dysfunction.This article emphasizes the therapeutic effect of Cordyceps militaris on PD,to provide a reference for further research on safe and effective natural alternatives for PD.