Simultaneous Determination of Six Components in Naoxinshutong Capsule by QAMS Method
Objective:To establish HPLC quantitative analysis of multi-components by single marker method(QAMS)for the simultaneous determination of 6 components(Danshensu,protocatechualdehyde,hydroxylsafflower yellow pigment A,rosmarinic acid,gastrodin and salviolic acid B)in Naoxinshutong capsule,and using external standard method(ESM)verify the feasibility and adaptability of this method for quality control in Naoxinshutong capsules.Methods:Using Danshensu as internal reference,the relative correction factors between salvianol and other 5 ingredients are established,and the contents of each component of Naoxinshutong capsule are calculated to achieve one measurement and multiple evaluation.Results:The relative correction factors of Danshensu are 1.025,2.157,0.760,1.820 and 6.224 with other 5 ingredients.There is no significant difference in the content of 6 components in 9 batches of Naoxinshutong capsules by QMAS and ESM(relative error lower than 5%).Conclusion:With Danshensu as the internal standard,the content of 6 components in Naoxinshutong capsule is determined by QMAS.The method is reliable and accurate,and can be used for the quality control of Naoxinshutong capsule.
quantitative analysis of multi-components by single markerrelative correction factorsNaoxinshutong capsuleHPLCexternal standard method
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