Study on the Effect of Flavonoids from Flaxseed Meal on Reducing Lipid and Glucose
Objective:To investigate the effect of flavonoids from flaxseed meal on abnormal metabolism of blood glucose and lipid in mice fed with high fat diet.Methods:In vitro experimental part,the scavenging effects of flavonoids from flaxseed meal on superoxide radicals,and their inhibitory effects on α-glucosidase and α-amylase activities are analyzed;animal experiment part,40 Kunming mice are randomly and evenly divided into 4 groups,normal control group(CON),high-fat diet group(HF),low-dose flavonoid group(LH)and high-dose flavonoid group(HH);after 5 weeks of continuous feeding,the levels of blood glucose,blood lipid and antioxidant enzyme are analyzed.Results:Flavonoids from flaxseed meal could scavenge superoxide radical,inhibit α-glucosidase activity and α-amylase activity;high-fat diet could abnormalities the level of blood glucose and blood lipid and decrease the activity of antioxidant enzymes in mice;flavonoids from flaxseed meal could significantly increase the activity of antioxidant enzymes in mice,and significantly improve the abnormal level of blood lipids and blood glucose concentration.Conclusion:Flavonoids from flaxseed meal has the effect of intervening the abnormal metabolism of blood glucose and lipid in mice caused by high-fat diet and reducing oxidative stress.
flavonoids from flaxseed mealhigh-fat dietmiceblood glucose and blood lipidsantioxidants
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