In this paper,polyethersulfone microporous membranes with different pore sizes are prepared by non-solvent-based phase separation method through orthogonal experiments and film-forming process modulation,and then processed into filters and finally assembled into infusion devices.The effects of the composition of the casting solution,ambient humidity,air bath time,the composition of the solidification bath and the temperature of the solidification bath on the pore size of the membrane,the infusion flow rate and the filtration rate of the infusion filter are systematically investigated.The experimental results show that:the mass fraction of polyethersulfone is 12.5%,the mass fraction of polyvinylpyrrolidone is 5.5%,the mass fraction of deionized water is 6%,the relative humidity of the environment is 60%～80%,the time of the air bath is 240 s,the mass fraction of dimethylacetamide in the coagulation bath(a mixture of dimethylacetamide/deionized water)is 55%,and the temperature of the coagulation bath is 50℃.Under the experimental conditions,the infusion flow rate is 66 mL/min,the filtration rate is 98.2%,and the pore size is 4.774 µm to achieve 5 µm pore size regulation.This study provides a useful reference not only for pore size regulation of filter membranes used in medical filters,but also helps to improve the purity of infused fluids and reduce the occurrence of complications in clinical practice.
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