Objective:To investigate the protective effect of Jarrah Honey(JH)on alcoholic liver injury in mice.Methods:Fifty mice are randomly divided into five groups:control group,model group,positive control group(common honey 15 g/kg)and JH low and high dose groups(5 g/kg,15 g/kg).After intragastric administration for 15 consecutive days,from the 16th to the 18th day,all mice except those in the blank control group are administered with alcohol at a dose of 15 mL/kg by gavage to establish an acute liver injury model.The protective effect of JH on acute alcoholic liver injury is comprehensively evaluated by calculating the liver index of mice,detecting the activity of alanine aminotransaminase(ALT)and aspartate aminotransferase(AST)in serum,the content of liver antioxidant enzymes,inflammatory factors and liver pathological observation.Results:Compared with blank control group,the liver index of the model group mice is significantly increased,the activities of ALT and AST in serum are increased,the antioxidant capacity of the liver is reduced,inflammatory reactions occurred,and liver cell degeneration occurred,indicating the successful establishment of the model;compared with the model group,the liver index of mice in the low and high dose JH groups is significantly reduced,and the activities of ALT and AST in serum are reduced.The levels of antioxidant enzymes catalase(CAT),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the liver are increased,and the inflammatory response is improved.The degree of liver tissue damage is also reduced.Conclusion:JH has a certain protective effect on alcoholic liver injury,and there is a dose effect relationship.When the dosage is 15 g/kg,JH can effectively reduce the degree of alcoholic liver injury.
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