Objective:An inductively coupled plasma atomic emission spectrometry(ICP-AES)method is developed for the determination of silicon,boron,aluminum and barium in levetiracetam injection.Methods:The samples are directly analyzed by ICP-AES after acidification,and the detection wavelengths are 288.158 nm for silicon,249.772 nm for boron,396.152 nm for aluminum and 493.408 nm for barium.Establish standard equations to examine instrument precision,sample repeatability,and recovery.Results:The linear range is as follows:silicon 0.5～5.0 mg/L,boron 0.1～1.0 mg/L,aluminum 1.0～10.0 mg/L,barium 0.01～0.10 mg/L,the linear correlation coefficients are all greater than 0.999 5;detection limits:silicon 0.044 mg/L,boron 0.006 mg/L,aluminum 0.017 mg/L and barium 0.000 5 mg/L;standard recoveries are 96.3%～103.1%for silicon,90.0%～95.0%for boron,101.3%～106.0%for aluminum,102.0%～105.0%for barium.Conclusion:The method is rapid,accurate,sensitive,and is suitable for the study of the content change of trace elements in drugs form packaging materials.
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