Acetylation is a common epigenetic modification in cancer,which exists in both RNA and protein.This modification plays an important role at both transcriptional and protein levels.It is known that the highly conserved RNA modification,N4-acetylcytidine(ac4C),as a post-transcriptional chemical modification of RNA,stabilizes mRNA,enhances transcriptional efficiency during translation,and aids in the accurate reading of particular nucleotide sequences.Protein acetylation is a reversible post-translational modification(PTM)that regulates important cellular processes such as proliferation,DNA damage repair and cell cycle progression.These processes are impacted and have the potential to cause cancer when the modification balance is disrupted.In recent years,many studies have found that acetylation modification plays a key regulatory role in the occurrence and development of colorectal cancer.Therefore,the study of the role of acetylation modification in colorectal cancer is helpful to understand the pathogenesis of cancer and provide new targets and strategies for cancer treatment.This article will review the previous studies on acetylation modification and the related studies on acetylation modification in colorectal cancer.
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