γδT cells are a distinct subset of T cells whose TCRs consist of γ chains and δ chains,different from conventional αβT cells.γδT cells exhibit characteristics of both innate and adaptive immunity,and play important roles in anti-cancer and anti-infective immunity.γδT cells have recently gained considerable attention as an attractive tool for cancer immunotherapy.This article reviews the main subsets of γδT cells,the mechanisms by which γδ T cells recognize and fight tumors,and the research progress of γδ T cells in tumor immunotherapy.
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