Camptothecin and its derivatives can form complexes with DNA topoisomerases,prevent DNA replication and RNA synthesis,and inhibit the growth of tumors,making them highly promising in tumor therapy.However,these compounds have drawbacks such as structural instability,poor solubility,and high toxicity,which limit their clinical application.Nanotechnology can enhance the water solubility and stability of camptothecin and improve its efficacy.Additionally,antioxidant drugs can eliminate the large amounts of reactive oxygen species produced by oxidative stress in the tumor microenvironment and exert an antioxidant effect for tumor inhibition.Therefore,using antioxidant nanomaterials as a drug delivery vehicle for camptothecin to form a camptothecin-antioxidant nanomedicine may provide a synergistic effect in tumor therapy.This article mainly reviews the research progress of the camptothecin-antioxidant nanomedicine delivery system.
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