Effects of Pluronic/TPGS co-Modification on the Physicochemical Properties and Release Behavior of Curcumin Liposomes
In order to improve the encapsulation effect and storage stability of liposomes,Pluronic F87 and tocopheryl polyethylene glycol 1000 succinate(TPGS)co-modified curcumin liposomes are constructed by thin film dispersion method combined with dynamic high-pressure microfluidization technology.The effects of Pluronic F87 and TPGS mass ratio on the physicochemical properties and in vitro release behavior of the carrier are investigated.The results show that with the increase of TPGS ratio,the particle size of curcumin liposomes decrease,the dispersibility is good,and the microscopic morphology is spherical.The in vitro release behavior show that curcumin liposomes show the characteristics of slow release after initial burst release.With the increase of TPGS ratio,the cumulative release of curcumin is lower.This study provides new ideas for the development of new liposomes and their application in drug encapsulation and sustained release.
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