Effect of Astragaloside Extract on Periodontal Tissue Injury in Periodontitis Model Rats
Objective:To analyze the effects of astragaloside extract on periodontal tissue injury in periodontitis model rats.Methods:A total of 94 healthy adult male SD rats are selected for modeling.The rats are randomly divided into study group(injection of astragaloside extract after modeling)and control group(injection of sodium chloride solution after modeling)by random number table method.Probing depth(PD),plaque index(PLI),sulcus bleeding index(SBI),Inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-12]and therapeutic effect of the two groups are compared before and after the experiment.Results:After intervention,the contents of PD,PLI,SBI,TNF-α,IL-6 and IL-12 in the two groups of rats are significantly reduced.Comparison between groups found that the PD[(2.26±0.38)mm],PLI[(0.61±0.15)value]and SBI[(1.38±0.32)value]of the group treated with astragaloside extract are significantly lower than those of the control group,the index values of which are respectively(3.49±0.42)mm,(1.52±0.76)value and(2.54±0.47)value;the value of TNF-α[(136.55±5.26)pg/mg],IL-6[(41.09±2.71)pg/mg]and IL-12[(32.01±4.06)pg/mg]in study group are significantly lower than those in control group,the index values of which are respectively(194.26±7.26)pg/mg,(65.39±4.28)pg/mg and(45.03±5.00)pg/mg;the total effective rate of the study group(93.62%)is significantly higher than that of the control group(82.98%).Conclusion:Astragaloside extract can reduce the inflammatory damage,periodontal probing depth,plaque index and sulcus bleeding index in the rat periodontitis model,so its clinical application value should be further explored in the treatment of periodontitis.
astragaloside extractperiodontitisinflammatory injuryprobing depthplaque index
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