Taking the Green Process Optimization and Improvement of Cyclohexanone Preparation as an Example to Investigate the Reform of Organic Chemistry Experimental Teaching
On the basis of the original experimental textbook,this paper intends to make green improvements to the preparation process of cyclohexanone.Using cyclohexanol as the starting material and pyridine chlorochromate as the oxidant,cyclohexanone is prepared efficiently without addition of any catalysts.The effects of the amount of oxidizing agent,reaction temperature as well as the reaction time for the yield of cyclohexanone are investigated.The optimum process conditions are obtained as follows:cyclohexanol of 42 mmol,pyridine chlorochromate of 35 mmol,reaction temperature of 60℃,reaction time of 80 min,and the highest yield of cyclohexanone is 81%.The oxidant used in this paper is stable and low toxicity,and the amount of reagents is greatly reduced,which is in according with the development direction of green chemistry.
NETL
NSTL
万方数据
