以环己酮制备的绿色工艺优化改进为例探讨有机化学实验教学改革
Taking the Green Process Optimization and Improvement of Cyclohexanone Preparation as an Example to Investigate the Reform of Organic Chemistry Experimental Teaching
谢艳军 1龚慧玲 1邓晋 1童家俊 1罗王虎 1谭建平 1易兵1
作者信息
- 1. 湖南工程学院 材料与化工学院,湖南湘潭 411104
- 折叠
摘要
本文在原实验教材的基础之上,对环己酮的制备工艺进行绿色化改进.采用环己醇为反应物,氯铬酸吡啶盐为氧化剂,无须催化剂,可高效制备环己酮.通过考察氧化剂的用量、反应温度及反应时间对环己酮产率的影响,实验得到最优工艺条件为环己醇42 mmol,氯铬酸吡啶盐35 mmol,反应温度60℃,反应时间80 min,环己酮的产率为81%.与传统实验方案相比,该方案所用氧化剂稳定、低毒,试剂用量有所降低,符合绿色化学发展要求.
Abstract
On the basis of the original experimental textbook,this paper intends to make green improvements to the preparation process of cyclohexanone.Using cyclohexanol as the starting material and pyridine chlorochromate as the oxidant,cyclohexanone is prepared efficiently without addition of any catalysts.The effects of the amount of oxidizing agent,reaction temperature as well as the reaction time for the yield of cyclohexanone are investigated.The optimum process conditions are obtained as follows:cyclohexanol of 42 mmol,pyridine chlorochromate of 35 mmol,reaction temperature of 60℃,reaction time of 80 min,and the highest yield of cyclohexanone is 81%.The oxidant used in this paper is stable and low toxicity,and the amount of reagents is greatly reduced,which is in according with the development direction of green chemistry.
关键词
环己酮/有机化学/绿色工艺/实验教学改革Key words
cyclohexanone/organic chemistry/green process/experimental teaching reform引用本文复制引用
基金项目
湖南省自然科学基金(2023JJ30189)
湖南工程学院教学改革研究项目(22045)
湖南工程学院教学改革研究项目(23004)
湖南工程学院研究生科研创新项目(YC202215)
出版年
2024
NETL
NSTL
万方数据