Acyl coenzyme A(acyl-CoA)is an intermediate of lipid metabolism and is involved in a number of metabolic pathways,such as fatty acid synthesis and degradation,transcription factor activation,post-translational modification of proteins,and energy metabolism,which plays an important role in the life activities of organisms.The dysregulation of acyl-CoA will affect various physiological and pathological processes in organisms,leading to a variety of diseases such as hepatocellular carcinoma,diabetes mellitus,and heart disease.Therefore,understanding the metabolic function of acyl-CoA in these diseases is instructive for clinically targeted therapy.In this review,we will present the structure and classification of acyl-CoA,the metabolic pathways involved,the metabolic regulation of acyl-CoA in some common diseases,and discuss the potential of utilizing acyl-CoA as a clinical target in the future therapy.
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