摘要
酰基辅酶A是脂质代谢的中间体,参与脂肪酸合成和降解、转录因子活化、蛋白质翻译后修饰以及能量代谢等一系列代谢途径,在生物体的生命活动中发挥着重要作用.当酰基辅酶A发生紊乱时,会影响生物体的各种生理和病理过程,进而引起各种疾病如肝细胞癌、糖尿病和心脏病等.因此,了解酰基辅酶A在这些疾病中的代谢功能对于临床靶向治疗有指导性意义.本文将从酰基辅酶A的结构和分类、参与代谢通路、酰基辅酶A在一些常见疾病中的代谢调控等方面进行综述,并对今后酰基辅酶A在疾病的临床靶向治疗方面的应用进行展望.
Abstract
Acyl coenzyme A(acyl-CoA)is an intermediate of lipid metabolism and is involved in a number of metabolic pathways,such as fatty acid synthesis and degradation,transcription factor activation,post-translational modification of proteins,and energy metabolism,which plays an important role in the life activities of organisms.The dysregulation of acyl-CoA will affect various physiological and pathological processes in organisms,leading to a variety of diseases such as hepatocellular carcinoma,diabetes mellitus,and heart disease.Therefore,understanding the metabolic function of acyl-CoA in these diseases is instructive for clinically targeted therapy.In this review,we will present the structure and classification of acyl-CoA,the metabolic pathways involved,the metabolic regulation of acyl-CoA in some common diseases,and discuss the potential of utilizing acyl-CoA as a clinical target in the future therapy.
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