Deuterium(D)is a stable isotope of hydrogen.Deuterium depleted water(DDW)can be produced by specific techniques as reducing the deuterium content of natural water.Multiple studies in vivo and in vitro have shown that drinking DDW can enhance the body's antioxidant capacity and immune regulation,playing an anti-tumor role.It is non-toxic and convenient to drink.This article focuses on the anti-tumor mechanism and related application research progress of DDW,in order to provide new formulations for clinical tumor adjuvant therapy.