DNA porphyrin hybrid molecules,as a new type of organic biological hybrid material,have attracted widespread attention in the fields of chemistry and biological sciences due to their unique physical and chemical properties such as excellent optical properties and good water solubility.This type of hybrid molecule combines the biological activity and recognition of DNA with the photosensitivity and fluorescence properties of porphyrin molecules,making them show great potential in multiple fields such as photodynamic therapy,biosensing,and fluorescence imaging.This article mainly discusses the research progress of non covalent and covalent synthesis techniques for DNA porphyrin hybrid molecules,and looks forward to their application prospects.